Este estudio sintetiza el estado en que se encuentra el catolicismo en la España de la segunda década del siglo XXI, en una perspectiva evolutiva. Para ello damos cuenta del ciclo en que se encuentra su dinámica y modelo de Iglesia, así como las dimensiones y su estructura. En resumen, la Iglesia católica española está iniciando un cambio cultural profundo en un nuevo ciclo impulsado desde Roma que procura una nueva relación sinodal en el interior de la Iglesia, y el (...) fomento de la cultura del encuentro en la relación con las instituciones modernas. En cuanto a las dimensiones, la comunidad católica está formada en 2024 por el 55% de los españoles (en 55 años, desde 1970, ha perdido 40 puntos porcentuales). El 15% de los españoles son católicos practicantes y el 28% de españoles son católicos que nunca o casi nunca participa en eucaristías. En total, 26,28 millones de personas en España. Respecto a la estructura, encontramos una tendencia al fortalecimiento de casi todas sus instituciones parroquiales, sociales, educativas y culturales, con tal cantidad de centros y actividad, que constituye una singularidad en la sociedad civil por su tamaño, capilaridad e incidencia. El futuro de las religiones es incierto pues depende en gran parte de cómo desarrollan el carisma, pero, pese a la reducción de sus miembros, sigue siendo no solamente la mayor realidad de la sociedad civil española, sino que previsiblemente lo seguirá siendo a lo largo de todo el siglo XXI. (shrink)

The purpose of this study is to examine how workgroup diversity can be managed through specific strategic human resource management systems. Our review shows that ‘affirmative action’ and traditional ‘diversity management’ approaches have failed to simultaneously achieve business and social justice outcomes of diversity. As previous literature has shown, the benefits of diversity cannot be achieved with isolated interventions. To the contrary, a complete organizational culture change is required, in order to promote appreciation of individual differences. The paper contributes to (...) this discussion by exploring the implications of this change for human resource management, and explaining how the systems of practices should be changed when they are directed to diverse groups. The model designed to test this notion includes: (1) demographic and human capital diversity as independent variables, (2) group performance (measured as innovation outcomes) as the dependent variable and, (3) the orientation of the strategic human resource management system as a potential moderator of this relationship. The main conclusion of the empirical analysis developed is that different patterns of human resource management practices can be used, depending on the type of diversity that the organization faces, and the specific effects that it wishes to manage. Concretely, three alternative management systems are identified in this paper, with different moderating effects. This result has interesting implications for human resource management professionals, explained in the last section. The limitations of this study are also discussed, as well as some issues that future research in this field should address. (shrink)

The formalization of abductive reasoning has received increasing attention from logicians. However, few work is found beyond abduction in propositional logic, given that in a first order formalism, the undecidability problem naturally appears, and therefore an abductive problem cannot even be appropriately formulated. Still, many applications in artificial intelligence allow finite domains to work with, and this gives an opportunity to apply abduction in first order logic with restricted domains. In this paper, we present an approach to abductive reasoning in (...) C-structures, first order structures with a finite domain in which each of its elements has a corresponding constant representing its interpretation. By using semantic tableaux with bounded depth, that is, C-tableaux (a modification of N-tableaux, introduced by the authors in previous papers) and δ-resolution calculus, we build an effective procedure for the searching of minimal abductive solutions within the proposed semantics. (shrink)

In this work we define, in a general way, an algebraic semantics for the logics of the hierarchy InPk. This semantics is defined by means of an alternative construction, with respect to the usual algebraic semantics, and it is known in the literature as Twist-structures semantics. Besides that, we modify such construction, defining the so-called ω-Twist-structures here. This adaptation allows us to prove adequacy theorems for every logic of the hierarchy InPk.

Patients’ beliefs about the effectiveness of their treatments are key to the success of any intervention. However, since these beliefs are usually formed by sequentially accumulating evidence in the form of the covariation between the treatment use and the symptoms, it is not always easy to detect when a treatment is actually working. In Experiments 1 and 2, we presented participants with a contingency learning task in which a fictitious treatment was actually effective to reduce the symptoms of fictitious patients. (...) However, the base-rate of the symptoms was manipulated so that, for half of participants, the symptoms were very frequent before the treatment, whereas for the rest of participants, the symptoms were less frequently observed. Although the treatment was equally effective in all cases according to the objective contingency between the treatment and healings, the participants’ beliefs on the effectiveness of the treatment were influenced by the base-rate of the symptoms, so that those who observed frequent symptoms before the treatment tended to produce lower judgments of effectiveness. Experiment 3 showed that participants were probably basing their judgments on an estimate of effectiveness relative to the symptom base-rate, rather than on contingency in absolute terms. Data, materials, and R scripts to reproduce the figures are publicly available at the Open Science Framework. (shrink)

To begin with -- Genealogy of the cerebral subject -- Disciplines of the neuro -- Cerebralizing distress -- Brains on screen and paper -- Up for grabs.

If personhood is the quality or condition of being an individual person, brainhood could name the quality or condition of being a brain. This ontological quality would define the `cerebral subject' that has, at least in industrialized and highly medicalized societies, gained numerous social inscriptions since the mid-20th century. This article explores the historical development of brainhood. It suggests that the brain is necessarily the location of the `modern self', and that, consequently, the cerebral subject is the anthropological figure inherent (...) to modernity (at least insofar as modernity gives supreme value to the individual as autonomous agent of choice and initiative). It further argues that the ideology of brainhood impelled neuroscientific investigation much more than it resulted from it, and sketches how an expanding constellation of neurocultural discourses and practices embodies and sustains that ideology. (shrink)

Starting from Proust’s distinction between the self-attributive and self-evaluative views on metacognition, this paper presents a third view: self-mindshaping. Based on the notion of mindshaping as the core of social cognition, the self-mindshaping view contends that mindshaping abilities can be turned on one’s own mind. Against the self-attributive view, metacognition is not a matter of accessing representations to metarepresent them but of giving shape to those representations themselves. Against the self-evaluative view, metacognition is not blind to content but relies heavily (...) on it. We characterize our view in terms of four issues that, according to Proust, distinguish the previous approaches, namely, whether metacognitive mechanisms are the same as those employed to access other minds, whether metacognitive control requires conceptual representation, whether metacognition is propositional, and whether metacognitive access is linked to mental action. After describing some of the mechanisms for self-mindshaping, we show how this view regards metacognition as grounded on social interaction mechanisms, conceptually driven, possibly, but not necessarily, propositional, and engaged in the practical regulation of mental states. Finally, we examine the prospects for the primacy of self-mindshaping as the primary metacognitive function. We argue that self-attributive processes typically subserve the practical goals emphasized by the mindshaping view, and that the evaluative role played by procedural metacognition can be grounded on social cues rather than on experiential feelings. Even if this is not enough to claim the primacy of self-mindshaping, it still appears as a third kind of metacognition, not reducible to the other two. (shrink)

The name of the Genevan critic Jean Starobinski will most likely evoke masterful\nreadings of Rousseau and Montaigne, or insightful reconstructions of the world\nof the Enlightenment. With the possible exception of the history of melancholy,\nmuch more rarely will it be associated with the history of psychology and\npsychiatry. A small number of the critic’s contributions to this field have\nappeared in some of his books. Most of them, however, remain scattered, and\nnothing suggests that they are known as widely as they deserve.\nStarobinski’s work in (...) the history of psychology, psychiatry and psychoanalysis\nis exemplary in its perspective of the problematic relations between\npsychological concepts and experiences, and between medical thought and the\nlarger culture. (shrink)

There is no systematic knowledge about how individuals with Locked-in Syndrome experience their situation. A phenomenology of LIS, in the sense of a description of subjective experience as lived by the ill persons themselves, does not yet exist as an organized endeavor. The present article takes a step in that direction by reviewing various materials and making some suggestions. First-person narratives provide the most important sources, but very few have been discussed. LIS barely appears in bioethics and neuroethics. Research on (...) Quality of Life provides relevant information, one questionnaire study explores the sense of personal continuity in LIS patients, and LIS has been used as a test case of theories in “embodied cognition” and to explore issues in the phenomenology of illness and communication. A systematic phenomenology of LIS would draw on these different areas: while some deal directly with subjective experience, others throw light on its psychological, sociocultural and materials conditions. Such an undertaking can contribute to the improvement of care and QOL, and help inform philosophical questions, such as those concerning the properties that define persons, the conditions of their identity and continuity, or the dynamics of embodiment and intersubjectivity. (shrink)

For thousands of years, people have used nature to justify their political, moral, and social judgments. Such appeals to the moral authority of nature are still very much with us today, as heated debates over genetically modified organisms and human cloning testify. The Moral Authority of Nature offers a wide-ranging account of how people have used nature to think about what counts as good, beautiful, just, or valuable. The eighteen essays cover a diverse array of topics, including the connection of (...) cosmic and human orders in ancient Greece, medieval notions of sexual disorder, early modern contexts for categorizing individuals and judging acts as "against nature," race and the origin of humans, ecological economics, and radical feminism. The essays also range widely in time and place, from archaic Greece to early twentieth-century China, medieval Europe to contemporary America. Scholars from a wide variety of fields will welcome The Moral Authority of Nature, which provides the first sustained historical survey of its topic. Contributors: Danielle Allen, Joan Cadden, Lorraine Daston, Fa-ti Fan, Eckhardt Fuchs, Valentin Groebner, Abigail J. Lustig, Gregg Mitman, Michelle Murphy, Katharine Park, Matt Price, Robert N. Proctor, Helmut Puff, Robert J. Richards, Londa Schiebinger, Laura Slatkin, Julia Adeney Thomas, Fernando Vidal. (shrink)

Since its emergence in the early 2000s, neuroethics has become a recognized, institutionalized and professionalized field. A central strategy for its successful development has been the claim that it must be an autonomous discipline, distinct in particular from bioethics. Such claim has been justified by the conviction, sustained since the 1990s by the capabilities attributed to neuroimaging technologies, that somehow ‘the mind is the brain’, that the brain sciences can illuminate the full range of human experience and behavior, and that (...) neuroscientific knowledge will have dramatic implications for views of the human, and challenge supposedly established beliefs and practices in domains ranging from self and personhood to the political organization of society. This article examines how that conviction functions as neuroethics’ ideological condition of possibility. (shrink)

From the classic Frankenstein of 1931 to Matrix, which offers a version of the philosophical fable of the brain in a vat and on to Self/less, in which the consciousness of a dying tycoon is transferred to a younger man’s body, cinema has variously explored the relationship between personhood and the body by means of fictions concerning the brain and its contents.1 From the crude disembodied brains of 1950s B-movies to the neuroimaging visuals of 21st-century cyberpunk, these films localize individuality (...) essentially in the brain, and make personal identity transcend the body’s demise by transplanting the brain into other, typically younger or at least healthier bodies.... (shrink)

IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

ArgumentSeeing a prodigious cure happen and then testifying about it certainly differs from attending an air pump experiment in order to bear witness to it. Yet early-modern saint-making and the “new” or “experimental philosophy” shared juridical roots, and thereby an understanding of the role of testimony for the establishment of “matters of fact” and for the production of legitimate knowledge. The reforms carried out after the Council of Trent, especially during Urban VIII's pontificate, of the juridical procedures for saint-making in (...) the Catholic Church implied a new attitude towards the examination of proposed miracles. Most of these miracles were healings. While the appeal to medical expertise had long been common, and skepticism had often manifested itself regarding cures or extraordinary bodily phenomena, both were now given formal status. Miracle inquests henceforth leaned towards refuting miraculousness by means of natural explanations. The procedure was systematized in a treatise published in the 1730s by Prospero Lambertini. The combination of Lambertini's work with the canonization causes in which he acted as the “devil's advocate” in charge of disputing arguments favorable to a sainthood candidate allows for a reconstruction of the interplay between the juridical and scientific economies of saint-making, and of the role of testimony in the production of trust and evidence. (shrink)

This book explores the notion of endangerment which stands at the heart of a network of concepts, values and practices dealing with objects considered threatened by extinction, and with the procedures aimed at preserving them. It looks at some of the fundamental ways in which this process involves science, but also more than science: not only data and knowledge and institutions, but also affects and values. With a focus on endangerment sensibility, it encapsulates tensions between the normative and the utilitarian, (...) the natural and the cultural. (shrink)

L’histoire de la psychologie en tant que discipline autonome comporte non seulement des développements méthodologiques et institutionnels, mais aussi l’élaboration du concept même de psychologie et des représentations de sa place dans l’ordre des sciences. Si de telles représentations ne détenninent pas la constitution du champ professionnel ou la pratique concrète du psychologue, elles n’en expriment pas moins des idéaux épistémologiques et reflètent les changements qui s’opèrent au sein de la discipline. Nous donnerons d’abord une vue générale de la position (...) de la psychologie au XVIIe et au VXIIIe siècle, puis nous esquisserons l’histoire de sa place dans l’ordre des sciences de Destutt de Tracy à Jean Piaget. Après avoir été la science des sciences des classifications hiérarchiques, la psychologie s’intègre aux autres sciences dans des schémas moins linéaires, voire circulaires, sans pour autant toujours perdre la prééminence gnoséologique et pédagogique que lui attribuèrent en premier les « psychologues » du XVIIIe siècle. (shrink)

Science in film, and usual equivalents such asscience on filmorscience on screen, refer to the cinematographic representation, staging, and enactment of actors, information, and processes involved in any aspect or dimension of science and its history. Of course, boundaries are blurry, and films shot as research tools or documentation also display science on screen. Nonetheless, they generally count asscientific film, andscience inandon filmorscreentend to designate productions whose purpose is entertainment and education. Moreover, these two purposes are often combined, and inherently (...) concern empirical, methodological, and conceptual challenges associated withpopularization,science communication, and thepublic understanding of science. It is in these areas that the notion of thedeficit modelemerged to designate a point of view and a mode of understanding, as well as a set of practical and theoretical problems about the relationship between science and the public. (shrink)

Although the eighteenth century is not a chief interest of historians of psychology, nor is the history of psychology a main topic of Enlightenment studies, the era has long qualified as what a textbook of modern philosophy called "the century of psychology". The present article examines such a historiographical paradox, and asks in what senses eighteenth-century might deserve that label. For the general historian of the Enlightenment, as for historians of logic, esthetics, moral philosophy, or education, the label is justified (...) by the psychologization experienced by those domains and others. The historian of the human sciences can agree because, especially in Germany, empirical psychology became during the eighteenth century an autonomous field of academic investigation. Psychology, under that name or otherwise, gained throughout Europe the highest rank in the hierarchy of the sciences. Moreover, insofar as its object was the soul united to, and interacting with the body, and to the extent that human beings were defined precisely by such a union and "commerce", psychology became the crucial anthropological science, on which all other branches of the "science of man" were said to depend. Finally, the development during the Aufklärung of a historical discourse about empirical psychology reveals the self-consciousness attained within the emerging field by the end of the eighteenth century. Weder ist das achtzehnte Jahrhundert für die Geschichte der Psychologie ein Schwerpunkt der Forschung, noch ist die Geschichte der Psychologie ein Hauptthema der Arbeiten über die Aufklärung. Trotzdem wurde diese Ära doch lange Zeit als das qualifiziert, was ein Textbuch der modernen Philosophie als "das Jahrhundert der Psychologie" bezeichnet. Der vorliegende Beitrag untersucht dieses historiographische Paradoxon, und fragt, inwiefern das achtzehnte Jahrhundert die Bezeichnung "Jahrhundert der Psychologie" verdient.Für den "allgemeinen" Historiker der Aufklärung genauso wie für die Historiker der Logik, der Ästhetik, der Moralphilosophie oder der Erziehung rechtfertigt sich die Bezeichnung aus der Psychologisierung, die diese und andere Gebiete erfahren haben. Der Historiker, der sich mit den Geisteswissenschaften beschäftigt, kann ihr ebenfalls zustimmen, da die empirische Psychologie, insbesondere in Deutschland, während des achtzehnten Jahrhunderts ein eigenständiges Feld auf dem Gebiet der akademischen Forschung wurde.Die Psychologie, sei es nun unter diesem oder einem anderen Namen, erreichte in der Hierarchie der Wissenschaften in ganz Europa den höchsten Rang. Darüber hinaus wurde sie zu einer kritischen anthropologischen Wissenschaft, von der gesagt wurde, daß alle anderen "Humanwissenschaften" auf ihr beruhen. Denn ihr Gegenstand war die mit dem Körper eine Einheit bildende und mit ihm zusammen agierende Seele, und in dem Umfang, in dem die Menschen präzise durch diese Einheit und durch das "commercium" beschrieben wurden. Letztendlich spiegelt die Entwicklung eines historischen Diskurses über die empirische Psychologie während der Aufklärung das Selbstbewußtsein wieder, das innerhalb dieses aufstrebenden Bereichs gegen Ende des achtzehnten Jahrhunderts erlangt wurde. (shrink)

Jean Piaget, connu comme créateur d'une théorie du développement de l'intelligence chez l'enfant, fut un naturaliste précoce. En 1912, à l'âge de seize ans, il prononça une conférence sur « La vanité de la nomenclature » dans le cadre des activités d'un club de jeunes naturalistes; le manuscrit de cette conférence a été retrouvé récemment. L'introduction à la présente édition du manuscrit essaie de montrer l'importance de ce dernier pour une biographie historique de Piaget. D'une part, « La vanité » (...) est à la fois l'expression la plus synthétique de l'intégration de son auteur au champ de l'histoire naturelle, et le premier signal de sa réorientation vers la biologie philosophique qui jouerait un rôle crucial dans son oeuvre ultérieure. D'autre part, le texte du jeune Piaget illustre la persistance du nominalisme dans la problématique post-darwinienne de l'espèce, et certaines relations entre cette problématique et la philosophie de Henri Bergson. Long before becoming the well-known creator of a theory of the development of intelligence in children, Jean Piaget was a naturalist. In 1912, at the age of sixteen, and as member of a young naturalists' club, he gave a talk called « The Vanity of Nomenclature », the manuscript of which was recently discovered. The introduction to the present edition of that manuscript aims at suggesting its significance for a historical biography of Piaget. On the one hand, Piaget's text is the best exponent of his integration into the field of natural history; however, it is also the first sign of his reorientation towards the philosophical biology that would play a fundamental role in his later work. On the other hand, « The Vanity » illustrates the persistence of nominalism in post-Darwinian thinking about the species, and reveals certain relations between Henry Bergson's philosophy and the history of biology. (shrink)

Establecer algún tipo de relación entre libertad y seguridad supone darle a cada una un contenido específico. En nuestro caso, hablaremos de la seguridad en el ámbito público y de la libertad como libertad política y civil. Partiendo de ahí se reflexionará sobre la seguridad y la libertad en relación al monopolio legítimo de la violencia (coaccion física) por parte del Estado moderno y su vinculación con la teoría democrática moderna. Y lo haremos siguiendo la disyuntiva existente entre política y (...) ética característica de las sociedades modernas. (shrink)

The title of this issue of Science in Context – “Believing Nature, Knowing God” – is intended to suggest the moral, emotional, and cognitive conditions in which the historical alliance of “nature” and “God” operated, and to make a more general point about knowing and believing. The production of scientific knowledge includes mechanisms for bringing about acceptance that such knowledge is true, and thus for generating a psychological state of belief. To claim to have knowledge of nature involves an attitude (...) of belief in certain epistemic values, in the procedures associated with them, and in the results to which they lead. “Nature,” both as a totality to be known, and as the sum of the results of research directed towards it, turns out to be an object of belief. (shrink)

Mediante un lenguaje paradojal, la obra de Miguel de Unamuno plantea de modo recurrente la cuestión de Dios, especialmente en el libro Del sentimiento trágico de la vida. Lo plantea bajo dos perspectivas: la del Dios pensado y la del Dios sentido. En ambos casos se trata de un Dios personal cuyo encuentro tiene lugar por vía de la intuición vivencial y el recogimiento. Se reconocen allí coincidencias con San Juan de la Cruz, y en general, con la mística al (...) privilegiar el sentimiento frente al entendimiento, la vivencia frente a la racionalidad. (shrink)

In 1913, the future psychologist and epistemologist Jean Piaget (1896-1980), then a seventeen-year-old naturalist, gave a talk criticizing 'the notion of the species according to the Mendelian school'. In it, he confounded Mendelism and mutationism, and misunderstood both. He attributed an environmental nature to the 'factors' postulated by Mendel's laws for inherited characteristics, and thought that mutations resulted from the appearance of a new environmental factor. Such misinterpretations are closely related to Piaget's assimilation of the Bergsonian critique of 'mechanistic' science (...) into his work in malacological taxonomy. (shrink)

Jean Starobinski on the Reason of Body In posthumous homage to Jean Starobinski (1920-2019) on the centennial of his birth, this article sketches his thought on the «reasons of the body», linking it to certain contemporary fields of research. Prolonging the «somatic turn» of the 1980s, more recent «emotional» and «interoceptive turns» claim to reintegrate the body into history, the humanities and the neurocognitive sciences. Starobinski’s perspective helps bring their limits to light. Conversely, approaching his critical enterprise from their vantage (...) point highlights its unique way of linking history and phenomenology, its sustained attention to the experience of the self and bodily self-awareness, and its demonstration of how the «reasons of the body» may be intimately bound to the literary expression that embodies them. (shrink)

In Dark City, people live in a city that is constantly in the dark. The city is in fact a laboratory constructed by a race of Strangers who live below the urban surface to do experiments aimed at discovering what makes human beings human. The Strangers will survive only by becoming like them. To find out what humanity is, but assuming it is essentially related to memory, every day they paralyze all human activity, extract memories from individuals, mix them, and (...) inject them back. When people wake up, they are totally different persons – but do not know it. This article examines how, starting with such a situation, Dark City explores the role of memory in personhood, the problem of authenticity, and the status of “false” memories in making the self, and how the connect to the experimental psychology and the neuroscience of memory. (shrink)

The existential situation of persons who suffer from the locked-in syndrome raises manifold issues significant to medical anthropology, phenomenology, biomedical ethics, and neuroethics that have not yet been systematically explored. The present special issue of Neuroethics illustrates the joint effort of a consolidating network of scholars from various disciplines in Europe, North America and Japan to go in that direction, and to explore LIS beyond clinical studies and quality of life assessments.

Argument“Deficit model” designates an outlook on the public understanding and communication of science that emphasizes scientific illiteracy and the need to educate the public. Though criticized, it is still widespread, especially among scientists. Its persistence is due not only to factors ranging from scientists’ training to policy design, but also to the continuance of realism as an aesthetic criterion. This article examines the link between realism and the deficit model through discussions of neurology and psychiatry in fiction film, as well (...) as through debates about historical movies and the cinematic adaptation of literature. It shows that different values and criteria tend to dominate the realist stance in different domains:accuracyfor movies concerning neurology and psychiatry,authenticityfor the historical film, andfidelityfor adaptations of literature. Finally, contrary to the deficit model, it argues that the cinema is better characterized by a surplus of meaning than by informational shortcomings. (shrink)

This essay explores the anonymous articles published by Sartre in Les Lettres Françaises, a clandestine journal edited by the National Committee of Writers in occupied France. The goal is to reconstruct the historical context of this intervention, examining its conceptual foundations and literary influences. Central to this exploration is an analysis of “Literature, this Freedom!”, in which the political significance of writing emerges from the experience of resistance. The investigation culminates in an assessment of the initial struggles of commitment.

Comparative study of the knowledge of IVF in medical students of universities with different ethical and humanistic valuesEstudo comparativo do conhecimento das técnicas de reprodução assistida em estudantes de Medicina de universidades com diferentes ideários éticos e humanísticosIn vitro fertilization continues to be presented as a relatively simple solution to produce a pregnancy without exposing the medical and ethical problems that this represents. This project consisted of conducting a survey to medical students from three medical schools in Mexico City with (...) different ethical and humanistic ideas with the aim of evaluating knowledge about IVF techniques and their ethical implications. The survey was applied to 404 medical students. Students in schools with personalistic ethics had a greater recognition of the bioethical principles involved in the use of these techniques. Knowledge of the technique and ethical issues involved in assisted reproduction could improve the sensitivity of medical students to ethical dilemmas that arise in their professional practice.Para citar este artículo / To reference this article / Para citar este artigoCantú-Quintanilla G, Vidal-Sentíes C, Marcó-Bach FJ, Camargo-Prieto F, Aguiñaga-Chiñas N, Contreras-Estrada D. Estudio comparativo del conocimiento de las técnicas de reproducción asistida en estudiantes de medicina de universidades con diferentes idearios éticos y humanísticos. Pers Bioet. 2020;24:166-176. DOI: https://doi.org/10.5294/pebi.2020.24.2.4Recibido: 04/09/2019Aceptado: 05/08/2020Publicado: 27/11/2020. (shrink)

The gene regulation function (GRF) provides an operational description of a promoter behavior as a function of the concentration of one of its transcriptional regulators. Behind this apparently trivial definition lies a central concept in biological control: the GRF provides the input/output relationship of each edge in a transcriptional network, independently from the molecular interactions involved. Here we discuss how existing methods allow direct measurement of the GRF, and how several trade‐offs between scalability and accuracy have hindered its application to (...) relatively large networks. We discuss the theoretical and technical requirements for obtaining the GRF. Based on these requirements, we introduce a simplified and easily scalable method that is able to capture the significant parameters of the GRF. The GRF is able to predict the behavior of a simple genetic circuit, illustrating how addressing the quantitative nature of gene regulation substantially increases our comprehension on the mechanisms of gene control. (shrink)